Magnesium Compounds Increase Aquaporin-3 in Human Epidermal Keratinocyte HaCaT Cells

Several studies have shown that magnesium can be a useful tool in preventing various skin disorders. However, the mechanism remains unclear. In this study, we analyzed by which improves function, focusing on water channel aquaporin-3 (AQP3), is cutaneous functional molecule. Magnesium compounds (magnesium acetate, chloride, sulfate, and lactate) were added to human epidermal keratinocyte HaCaT cells, mRNA protein expression levels of AQP3 analyzed. We also investigated acetate regulates expression. individually 6 hours later, level treated cells was significantly increased compared control cells. Among compounds, had strong effect markedly approximately 3.5 times 3 times. enhanced phosphorylation cAMP response element-binding (CREB), involved transcription. Furthermore, increase induced suppressed treatment with kinase A (PKA) inhibitor H-89. keratinocytes may skin-moisturizing effect. The magnesium-induced CREB associated activation cAMP/PKA pathway. Overall, for prevention age-associated xeroderma.